Both abiotic and microbial reactions take place on the scale of single pores and smaller. Thus, diffusion controlled processes (i.e., solute mixing and inter-phase mass transfer) at the pore scale have been identified as the limiting factors of biogeochemical reactions in field-scale applications. In recent years, modeling and experimental investigations of pore-scale processes have made considerable progress. Likewise, the description of field-scale transport has becomes mature. However, the challenge of incorporating information gained from pore-scale characterization and modeling efforts into larger-scale models and applications remains formidable. Upscaling rules that apply to conservative transport are mostly invalid when applied to mixing-controlled reactive transport. We solicit contributions that describe theory, numerical methods, and applications that integrate pore-scale results, or at least small-scale data and/or simulation results, into larger-scale (bio)reactive models. Contributions describing (1) multi-scale numerical methods for (bio)reactive transport, (2) efficient ways to assess mixing related quantities and transferring observations of conservative transport to reactive systems, (3) analytical approaches for the upscaling of mixing-related quantities, (4) and sound analysis of how to overcome pore-scale limitations of field-scale remediation are welcome.